学术动态 Academic Updates & Laboratory Milestones
细菌 PstSCAB 磷酸盐转运体结构与机制发表于 Nature CommunicationsPstSCAB phosphate transporter mechanism published in Nature Communications
利用冷冻电镜解析 PstSCAB 在静息、预转运及催化中间态的高分辨率结构，揭示细菌磷酸盐摄取的完整分子机制，为抗菌药物开发提供新靶点。Cryo-EM structures of PstSCAB in resting, pretranslocation, and catalytic intermediate states reveal the complete molecular mechanism of bacterial phosphate import, thereby providing new structural targets for antimicrobial drug development.
XPR1 磷酸盐输出蛋白结构解析发表于 Nature CommunicationsXPR1 phosphate exporter structure published in Nature Communications
揭示人源 XPR1 磷酸盐输出的结构基础，为原发性家族性脑钙化等相关疾病干预提供新靶点。Reveals the structural basis of phosphate export by human XPR1, providing new therapeutic targets for primary familial brain calcification and related disorders.
ACR-23 受体驱虫药物机制研究发表于 EMBO JournalACR-23 anthelmintic mechanism published in EMBO Journal
阐明单帕奈特与甜菜碱对线虫乙酰胆碱受体的分子效应，推动新型驱虫药开发。Elucidates the molecular effects of monepantel and betaine on C. elegans ACR-23, advancing new anthelmintic drug development.
昆虫味觉受体糖特异性结构基础发表于 Cell DiscoveryInsect gustatory receptor sugar specificity published in Cell Discovery
解析昆虫味觉受体识别糖类的结构机制，为农业害虫防治提供新的分子靶点。Structural mechanism of sugar recognition by insect gustatory receptors, providing new insights for agricultural pest control.
ENaC/DEG 超家族神经肽激活通道结构发表于 Nature Chemical BiologyENaC/DEG neuropeptide-activated channel structure published in Nature Chemical Biology
首次解析神经肽激活通道的高分辨率结构，揭示其独特门控机制。First high-resolution structure of a neuropeptide-activated channel, revealing its unique gating mechanism.
陈庆锋教授全职加入云南大学生命科学学院Prof. Chen joins Yunnan University full-time
正式加入云南大学生命科学中心/生命科学学院，开展跨膜蛋白质机器的结构与功能研究。Officially joined the School of Life Sciences, Yunnan University, to pursue structural and functional studies of transmembrane protein machines.